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Effective teamwork is crucial in high-stakes domains, yet it is highly challenging to achieve. Team members often must make decisions with limited information and under constraints on communication and time. Recognizing both the value of human coaches as well as the challenges of integrating them into practical settings, we envision AI-based coaching agents to enhance team coordination and performance. This extended abstract introduces AI Coaches and Coordinators, highlights key research questions from both human and AI perspectives that must be addressed to realize them, and summarizes our recent work in developing algorithms and systems to bring AI Coaches and Coordinators to fruition.more » « lessFree, publicly-accessible full text available May 28, 2026
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SeqScreen: accurate and sensitive functional screening of pathogenic sequences via ensemble learningBalaji, Advait; Kille, Bryce; Kappell, Anthony D.; Godbold, Gene D.; Diep, Madeline; Elworth, R. A. Leo; Qian, Zhiqin; Albin, Dreycey; Nasko, Daniel J.; Shah, Nidhi; et al (, Genome Biology)Abstract The COVID-19 pandemic has emphasized the importance of accurate detection of known and emerging pathogens. However, robust characterization of pathogenic sequences remains an open challenge. To address this need we developed SeqScreen, which accurately characterizes short nucleotide sequences using taxonomic and functional labels and a customized set of curated Functions of Sequences of Concern (FunSoCs) specific to microbial pathogenesis. We show our ensemble machine learning model can label protein-coding sequences with FunSoCs with high recall and precision. SeqScreen is a step towards a novel paradigm of functionally informed synthetic DNA screening and pathogen characterization, available for download atwww.gitlab.com/treangenlab/seqscreen.more » « less
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